In a new study, we described the identification plus the characterization of a completely new atypical opioid receptor with one of a kind detrimental regulatory properties towards opioid peptides.1 Our success confirmed that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is likewise a wide-spectrum s